For an overview and description of Transfeminine Science, please visit our Home page.


The authors for Transfeminine Science include Aly, Mitzi, Lain, Sam, and Luna.


Aly (“she/her”) is a transgender woman from California. She has a passionate interest in transfeminine hormone therapy. Aly began her transition in the early 2010s and has been studying the transgender medical literature since. She has a bachelor’s degree with summa cum laude distinction from a University of California. Aly also completed some of the pre-medicine curriculum and worked for a little under a year as an appointed volunteer faculty in research labs at the university.

Aly was a volunteer editor on Wikipedia for many years. She was a prolific medical editor for the online encyclopedia and contributed a large amount of content in the area of sex hormone pharmacology over time. Since then, Aly decided to retire from Wikipedia editing. When Aly has included inline citations to Wikipedia on Transfeminine Science, they have usually been to content that she herself authored.

Aly was closely involved with the online transgender community for many years, including on Reddit and Discord. On Reddit, she led r/MtFHRT for a few years, co-founded r/AskMtFHRT and r/TransBreastTimelines, and was previously a moderator of r/TransDIY.

➜ Articles by Aly


Mitzi (“she/they”) is a non-binary transfeminine person who lives in London, United Kingdom. She is prolifically active in DIY HRT communities, where she acts as an educator and advocates a harm reduction approach to self-medication. Mitzi frequently navigates situations that involve transgender homelessness, domestic violence, healthcare discrimination, and substance use both online and locally, and has held advisory roles for a variety of small grassroots organizations, including Trans Healthcare Network, Gender Construction Kit, and Bluelight.

Mitzi has a broad interest in medical academia, with a particular passion for endocrinology and psychopharmacology. She is an outspoken critic of her country’s transgender healthcare system, and has self-medicated for the duration of her own transition.

➜ Articles by Mitzi


Lain (“they/them”) is non-binary and transfeminine. They completed a bachelor’s degree in applied mathematics and studied bioinformatics and computational biology at the Rochester Institute of Technology in New York. After withdrawing from their Ph.D. program, Lain migrated to the much warmer climes of the San Francisco Bay Area to work in tech.

As a person entrenched in nightlife community, specifically raving, Lain reformed and ran a nightlife harm reduction non-profit chapter for over 3 years, Bay Area DanceSafe. At DanceSafe they produced harm reductive literature on pertinent drugs and organized harm reduction booths at various festivals and raves. Through this direct outreach to the nightlife community, Lain led volunteers providing peer education on drugs, consent, sex education, and other pertinent topics as well as substance adulterant testing and harm reduction interventions. As a chapter head, they advocated for the normalization of harm reduction and the reform of drug policy working with peer organizations such as the Drug Policy Alliance (DPA), the Students for Sensible Drug Policy (SSDP), the Multidisciplinary Association for Psychedelic Studies (MAPS), and also by speaking at several events in the Bay Area.

As Lain began to medically transition, they began to passionately research endocrinology and transgender medicine. Lain was involved with Transfeminine Science for a few years and wrote several articles on this site. However, Lain has since moved on and is now no longer involved with this site.

➜ Articles by Lain


Sam (“she/her”) is a transgender woman from London, United Kingdom. She has no formal medical or research qualifications, but has an intense interest in evidence-based medicine and adherence to the scientific method and has contributed several articles on the subject of transfeminine hormone therapy to Transfeminine Science. Her major research interests include the relatively uncommon to rare adverse effects of hormone therapy in transfeminine people, such as thromboembolism and other cardiovascular diseases. Specifically, she is interested in how the safety of different gender-affirming hormone therapy medications and dosages might compare. Sam has been reading and keeping up to date with the formal medical literature since she began to hormonally transition in 2018.

Sam was involved with Transfeminine Science for a few years and wrote several articles on this site. However, Sam has moved on and is now no longer writing new content for Transfeminine Science.

➜ Articles by Sam


Luna (Blahaj-type) (“she/they”) is a non-binary trans woman and computer scientist from the United Kingdom. She developed the advanced injectable estradiol simulator via modification of Aly’s original simulator code.


Transfeminine Science is no longer accepting contact inquiries. For questions and advice about hormone therapy, please refer instead to the online transgender community.


Transfeminine Science originated from the informational content on transfeminine hormone therapy that was created by transfeminine people in the r/MtFHRT community of the social media website Reddit. Aly began creating content in August 2018, with other authors soon joining the effort. The articles were later adapted and moved to Transfeminine Science, which was launched in October 2020. Transfeminine Science has served as a dedicated platform for the articles and for additional content since then.


The writers of Transfeminine Science are not medical professionals nor academic researchers. Transfeminine Science articles emulate the format of scientific journal articles, because this is an excellent format for scientific writing, but Transfeminine Science itself is not a scientific journal. The content on this site has not been formally published nor scholarly peer-reviewed. Readers should not take the content on Transfeminine Science as authoritative, but only as a supplementary resource to the information contained in transgender care guidelines and the medical literature in general.

Wherever possible, decisions about medical care should be made in partnership with a health care professional. We recognize that many transfeminine people are on do-it-yourself (DIY) hormone therapy however, and we aim to help inform this critical and underserved community of individuals as well.


Transfeminine Science is copyright of Aly and the other authors of Transfeminine Science. We reserve all rights. We ask that readers please don’t reproduce content from Transfeminine Science unless given permission from Aly (e.g., for translation projects). If permission to reproduce content is given, please appropriately attribute the content and link it back to the original page(s) on Transfeminine Science.